Indications and clinical use:
JELIDO® (lidocaine hydrochloride jelly) is indicated for:
- Surface anaesthesia and lubrication for:
- The male and female urethra during cystoscopy, catheterization, exploration by sound, and other endourethral operations
- Nasal and pharyngeal cavities in endoscopic procedures such as gastroscopy and bronchoscopy
- Proctoscopy and rectoscopy
- Tracheal intubation
- Symptomatic treatment of pain in connection with cystitis and urethritis
Pediatrics (2–18 years of age): Children should be given reduced doses commensurate with their age, weight, and physical condition.
Pediatrics (< 2 years of age): Lidocaine should be used with caution in children younger than two years of age as there are insufficient data to support the safety and efficacy of this product in this patient population at this time.
Geriatrics (> 65 years of age): Elderly patients should be given reduced doses commensurate with their age and physical condition.
Contraindications:
- Patients who are hypersensitive to this drug or to any ingredient in the formulation, including any non-medicinal ingredient, or any component of the container
- Patients with a known history of hypersensitivity to local anaesthetics of the amide type or to other components in the formulation
- Patients with congenital or idiopathic methemoglobinemia
- Infants ≤ 12 months of age who require treatment with methemoglobin-inducing agents (e.g., sulfonamides)
- Patients with glucose-6-phosphate dehydrogenase deficiency, which makes them more susceptible to drug-induced methemoglobinemia
Most serious warnings and precautions:
- PATIENTS SHOULD BE INSTRUCTED TO STRICTLY ADHERE TO THE RECOMMENDED DOSAGE: EXCESSIVE DOSAGE, OR SHORT INTERVALS BETWEEN DOSES, CAN RESULT IN HIGH PLASMA LEVELS OF LIDOCAINE OR ITS METABOLITES AND SERIOUS, AS WELL AS LIFE-THREATENING, ADVERSE EFFECTS, including methemoglobinemia.
- Use in children and infants (< 3 months): Ensure the caregiver understands to limit the dose and area of application and to prevent accidental ingestion. Children should be closely observed during and after use of lidocaine as they are at greater risk than adults for serious adverse events (e.g., methemoglobinemia).
Other relevant warnings and precautions:
- Lowest effective dose should be used
- Avoid contact with eyes
- Potential triggering agent for familial malignant hyperthermia
- In patients under general anaesthesia who are paralyzed, higher plasma concentrations may occur than in spontaneously breathing patients
- Unparalyzed patients are more likely to swallow a large proportion of the dose, which then undergoes considerable first-pass hepatic metabolism following absorption from the gut
- Endotracheal tube lubrication
- Avoid introduction of the jelly into the lumen of the tube
- Do not use to lubricate the endotracheal stylettes
- Topical anaesthetics used in the mouth may enhance the danger of aspiration
- Numbness of the tongue or buccal region may enhance unintentional biting trauma
- May temporarily impair locomotion or alertness
- Use with caution in patients with:
- Sepsis
- Traumatized mucosa at the area of application
- Epilepsy
- Severe shock
- Bradycardia
- Impaired cardiovascular function
- Hepatic disease or impaired renal function
- Known drug sensitivities
- Exercise caution when driving and operating machinery
- Exercise caution with use in all porphyric patients
- Reduced doses should be given in debilitated patients, acutely ill patients, and patients with sepsis
- Care should be taken during early pregnancy
For more information:
Consult the Product Monograph for important information relating to adverse events, drug interactions, and dosing that has not been discussed in this piece. The Product Monograph is also available by calling 1-888-550-6060.
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